Shatavari for Treating Pre and Post Menopausal Symptoms

Shatavari plus is a herbal formulation containing equimolar concentrations of standardised extracts of two important Ayurvedic herbs, shatavati and methika. A standardised herbal extract is a preparation, which contains a certain fixed proportion of the active constituent.

The formula effectively supplies phytoestogens to the female’s requirement thereby making formula highly efficacious in various diseases. Isoflavones belong to a group of compounds known as phyto-estrogens. The isoflavone content of soybean is 10 t0 20 times more than other plants. Isoflavones are found in Glycine max (soybean). Clinical research has demonstrated soy isoflavones to be effective in menstrual diseases. Shatavarins present in Shatavari are potent phyto-estrogens.

The formulation has tonic action which makes it indispensible for pre-menopausal and post-menopausal syndrome. It also cut-shorts complications of pregnancy particularly haemorrhage. Shatavari has Stanyajanana (galactagogue) property, which makes Shatavari Plus useful in cases of failing-lactation. Galactagogues stimulate the flow of milk.

Composition of Shatavari Plus:

Shatavari Extract 250mg
Fenugreek Extract – 250mg

Pharmacology of main ingredients

Shatavari

  • Gana or Classification according to Ayurveda: Balya, Kantaka panchmoola, Madhura skanda, Pitta prashmana and Vidarigandhadi.
  • Family: Liliaceae.
  • Botanical name: Asparagus racemosus
  • Synonyms: Sadabori (Hindi), Bahula, Chandravala, Dravidi, Ela, Kapotavarna, Kunati, Nistuki, Suksmaila, Tvisa (Sanskrit), Common asparagus (English).
  • Habitat: racemosus is found in India.
  • Morphology: racemosus is prickly and bushy twinner. Branches are spotted. Flowers are minute and white coloured. Fruit resembles with that of pea. Roots are brownish-white in colour, thin and starchy.
  • Chemical composition: Steroid saponins (shatavarins) and mucilage. A flavone has been reported.

Structure of Shatavarin

Fig: Structure of Shatavarin

  • Rasa (Taste): Madhura (Sweet) and Katu (Pungent).
  • Guna (Physical property): Laghu (Light) and Ruksha.
  • Virya (Potency): Usna (Hot).
  • Vipaka (Post digestion effect): Katu (Pungent).
  • Effect on Tridosha: Pacifies Vata, Pitta and Kapha.
  • Karma (Specific action): Shukra janana (Spermopiotic).
  • Therapeutics: racemosus is used in chronic bronchitis, urinary tract infection and oligozoospermia.
  • Parts used: Tubers.
  • Dose: Powder (3-6 G).
  • Formulations based on Shatavari: Narayan Taila, Shatavari ghrita and Shatavari mandura.
  • Research: A study by Gaitonde and Jetmalani reported the antioxytocic action of saponin isolated from racemosus on uterine muscle.

Methika

  • Gana or classification according to Ayurveda: Chaturabeeja.
  • Family:
  • Botanical name: Trigonella foenum-graceum
  • Synonyms: Methi (Hindi), Bastika, Methi, Methika, Peetabeeja, Rohiti, Selu, Vanamethika (Sanskrit) and Fenugreek (English).
  • Habitat: foenum-graceum is cultivated in India.
  • Morphology: foenum-graceum is an annual, hairy, sharp-smelling herb. Leaves trifoliate. Flowers white and fruit pod, hairy having greenish-brown seeds.
  • Chemical composition: Alkaloids (choline and trigonelline), coumarins (trigocoumarin and trimethyl coumarin), steroid saponins (disogenin and gitogenin), tannins, vitamins, minerals, fat, carbohydrates and proteins. Composition of seeds of foenum-graceum is tabulated below:

foenum

Table: It shows composition of seeds of T. foenum-graceum.

Trigonelline

Fig. Structure of Trigonelline

  • Rasa (Taste): Katu (Pungent).
  • Guna (Physical property): Laghu (Light) and Snigdha.
  • Virya (Potency): Ushna (Hot).
  • Vipaka (Post digestion effect): Katu (Pungent).
  • Effect on Tridosha: Pacifies Vata.
  • Karma (Action): Kasahara (Antitussive).
  • Therapeutics: foenum-graceum is used in the treatment loss of appetite, general debility and diabetes mellitus. The paste of the drug is applied in abscess and painful parts.
  • Contraindications: Bleeding diathesis.
  • Parts used: Whole plant and seeds.
  • Dose: Powder (1-3 G).
  • Formulations based on Methika: Methiadimodaka.

 

Technical detail of Shatavari Plus

  1. Trade name of the Ayurvedic medicinal product:

Shatavari Plus

  1. Composition:
  2. 1. See above
  3. Pharmaceutical form:

Capsule

  1. Clinical particulars

4.1: Therapeutic indications

Pre-menopausal syndrome, post-menopausal syndrome and failing lactation.

4.2: Posology and method of administration

The dosage of Shatavari Plus is 1 capsule twice or thrice a day, with lukewarm water, by oral route.

4.3: Contraindications

Shatavari Plus is safe within prescribed dose. It is strongly recommend that product should be taken under strict professional supervision.

4.4: Special warning and special precautions for use

Menorrhagia, metrorrhagia, dysfunctional uterine bleeding and vaginitis.

4.5: Interactions with other medicinal products and other forms of interaction

Synthetic progesterone.

4.6: Pregnancy and lactation

To be used under expert medical supervision.

4.7: Effects on ability to drive and use machines

Not established.

4.8: Undesirable effects

Not-reported.

4.9: Overdose:

Not established.

  1. Pharmacological properties

5.1: Pharmacodynamic properties

Unknown.

5.2: Pharmacokinetic properties

Unknown.

5.3: Preclinical safety data

The tolerability of Shatavari Plus based ingredients have been studied by means of multiple dosages in animal and human studies.

  1. Pharmaceutical particulars:

6.1: List of excipients

NA

6.2: Incompatibilities

Not known.

6.3: Shelf life

As per Ayurvedic Formulary of India

Conclusion

Shatavari plus is blend of two time-tested herbal ingredients having properties similar to female hormones, which make the formulation ideal for treating signs and symptoms associated with menopause. In addition, Shatavari plus is devoid of unpleasant side-effects of synthetic hormonal preparations. Shatavari plus can be better described as Hormonal Replacement Therapy of Herbal origin.

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