An Overview of K-Crush for Kidney Stones – Dr. Amrit

K-Crush is a polyherbal formulation containing potent lithontriptics or antilithic, renal-alkaliniser and neprhoprotective Ayurvedic herbs. K-Crush is an efficacious Ayurvedic formulation given in the treatment of nephrolithiasis or renal calculus. Ashamrighna (Lithontriptics) drugs help in dissolving kidney stones. Varuna (Cratevea nurvala) is included in this category. Mutrala (diuretics) are groups of drugs that produce increased urinary flow. Gokshura (Tribulus terresteris) and Punarnava (Boerrhavia diffusa) are diuretics. They are used in treating oedema.

Composition:

Bergenia ligulata 50 mg,

Crataeva nurvala 20mg,

Cucumis sativus 40mg

Elettaria cardamomum 20mg

Jawakshar 70mg

Mitha soda 70mg

Picrorhiza kurroa 40mg

Processed alum Compound 80mg,

Sodium chloride salt 50mg

Tribulus terrestris 40mg,

Details of Major Ingredients

Varuna

  • Gana or Classification according to Ayurveda: Arshoghana, Vatahmarinashana, and varunadi.
  • Family: Capparidaceae.
  • Botanical name: Cratavea nurvala Buch-Ham. syn religiosa Hook.f. & Thomas.
  • Synonyms: Baruna (Hindi), Kumaraka, Sveta, Sakavrksha, Varuna, Tiktashaka, (Sanskrit) and three-leaved caper (English).
  • Habitat: nurvala is found in India.
  • Morphology: nurvala is deciduous tree having long staled leaves and greenish – yellow flowers. Fruit is in form of berries.
  • Chemical composition: Saponin and tannins. Triterpenoids lupeol and varunol have been isolated from root and stem bark. Choline has been reported from water extract.
  • Rasa (Taste): Tikta (Bitter) and Kshaya (Astringent).
  • Guna (Physical property): Laghu (Light) and Ruksha.
  • Virya (Potency): Usna (Hot).
  • Vipaka (Post digestion effect): Katu (Pungent).
  • Effect on Tridosha: Pacifies pitta and kapha.
  • Karma (Action): Ashmarighana (Lithontriptic).
  • Therapeutics: Used in renal calculi and urinary tract infections.
  • Parts used: Bark.
  • Dose: Decoction (50-100 ml).
  • Formulations based on Daruharidra: Varunadi quatha.
  • Pharmacological investigations:
  1. A study reported anti-inflammatory activity of the alcohol ether extract of the bark of C. nurvala.
  2. A study reported antiseptic action of C. nurvala. The decoction prepared from the plant prevented urolithiasis.

Pasanbheda

  • Botanical name: Bergenia ligulata (Wall.) Engl.
  • Synonyms: Pasthachur (Hindi) and Ashmarghana, Asmabhedaka, Asmaribheda, Drsadbheda, Nagabehdana, Nagabhid, Pasana, Psanbheda, Silabheda (Sanskrit).
  • Habitat: ligulata is found in India.
  • Morphology: ligulata is a perennial branched herb. Rots red coloured and leaves ovate Flowers pink and fruit drupe.
  • Chemical composition: Coumarin (bergenin), gallic acid, tannic acid, minerals and wax.
  • Rasa (Taste): Tikta (Bitter) and Kshaya (Astringent).
  • Guna (Physical property): Laghu (Light) and Snigdha.
  • Virya (Potency): Usna (Hot).
  • Vipaka (Post digestion effect): Katu (Pungent).
  • Effect on Tridosha: Pacifies Vata, Pitta and Kapha.
  • Karma (Action): Asmaribhedeka (Lithinotriptic).
  • Therapeutics: ligulata is used in the treatment of renal calculus, leucorrhoea and opium poisoning
  • Parts used: Seeds.
  • Dose: Powder (1-3 G).
  • Clinical study: A study reported efficacy of Sveta parpati with Pasana bheda and Gokshura in the management of urolithiasis

Trapushpa

  • Botanical name: Cucumis sativus
  • Synonyms: Kheera (Hindi), Trapushpa (Sanskrit) and Cucumber (English).
  • Habitat: sativus is found in India.
  • Morphology: sativus is an annual climber. Leaves simple and dentate; flowers yellow. Fruit is pepo having many long-flat, white coloured seeds.
  • Chemical composition: Cucurbitacin, ash, rutin, minerals, oxalate and vitamins.
  • Rasa (Taste): Madhura (Sweet).
  • Guna (Physical property): Laghu (Light) and Ruksha.
  • Virya (Potency): Shita (Cold).
  • Vipaka (Post digestion effect): Madhura (Sweet).
  • Effect on Tridosha: Pacifies Pitta and Kapha.
  • Karma (Action): Mutrala (Diuretic).
  • Therapeutics: sativus is used in general debility, dysuria and jaundice.
  • Parts used: Fruit and seeds.
  • Dose:   Powder (3-6 G).

Ela (Suksmaila)

  • Gana or Classification according to Ayurveda: Haridradi, Kandughana, Kusthaghana, Mustadi, Tiktaskanda and Vishaghana,
  • Family: Zingiberaceae.
  • Botanical name: Elettaria cardamomum
  • Synonyms: Choti elachi (Hindi), Bahula, Chandravala, Dravidi, Ela, Kapotavarna, Kunati, Nistuki, Suksmaila, Tvisa (Sanskrit), lesser cardamom (English).
  • Habitat: cardamomum is found in Burma, India and Sri Lanka and Burma.
  • Morphology: cardamomum is perennial herb. Leaves are egg shaped and flowers are light green.   Seeds are oval having fibres at the end, dirty white colour, and having typical pungent odour.
  • Chemical composition: Volatile oil (containing cineole, limonene and sabinene), yellow colouring matter and ash.
  • Rasa (Taste): Madhura (Sweet) and Katu (Pungent).
  • Guna (Physical property): Laghu (Light) and Ruksha.
  • Virya (Potency): Ushna (Hot).
  • Vipaka (Post digestion effect): Katu (Pungent).
  • Effect on Tridosha: Pacifies Vata, Pitta and Kapha.
  • Karma (Specific action): Daha prashamana.
  • Therapeutics: cardamomum is used in cough, asthma, haemorrhoids and dysuria. It is given in debility with success. It is added to Ayurvedic purgative and laxative formulas for preventing gripping.
  • Parts used: Seeds.
  • Dose: Powder (0.5-1 G).
  • Formulations based on Ela (Suksmaila): Eladiaristha, Eladigutika and Eladivati.

Yavakshara (Alkali preparation of Barley)

A comparative study was conducted on 20 patients. 10 patients of Group I received Yava Kshara and remaining 10 patients were given an indigenous drug called GCP Compound for a period of 60 days. Statistical analysis showed that P – value of less than 0.05 was seen in Group I from 0 to 60 days course. There was no significant difference observed in the stone size in Group I when the actual value and calculated value were compared.

Technical detail of K-Crush

  1. Trade name of the Ayurvedic medicinal product: K-Crush
  1. Composition: See above
  2. Pharmaceutical form: Capsule
  1. Clinical particulars

4.1: Therapeutic indications

Nephrolithiasis or renal calculus, pyuria and crystalluria.

4.2: Posology and method of administration

The dosage of K-Crush is 1 capsule twice or thrice a day, with lukewarm water, by oral route.

4.3: Contraindications

K-Crush is safe within prescribed dose. It is strongly recommend that product should be taken under strict professional supervision.

4.4: Special warning and special precautions for use

High levels of blood uric-acid and urea.

4.5: Interactions with other medicinal products and other forms of interaction

Not established.

4.6: Pregnancy and lactation

Not recommended during pregnancy and lactation.

4.7: Effects on ability to drive and use machines

Not established.

4.8: Undesirable effects

Not-reported.

4.9: Overdose:

Not established.

  1. Pharmacological properties

5.1: Pharmacodynamic properties

Unknown.

5.2: Pharmacokinetic properties

Unknown.

5.3: Preclinical safety data

The tolerability of K-Crush based ingredients have been studied by means of multiple dosages in animals.

  1. Pharmaceutical particulars:

6.1: List of excipients

NA

6.2: Incompatibilities

Not known.

6.3: Shelf life

As per Ayurvedic Formulary of India

Conclusion

Kidney stone is a common health ailment. It has been observed that it is prone to recurrence. Sometimes repeated operations are not helpful. K-Crush is an ideal combination of herbs having lithotripic (stone-dissolving) and alkaliniser properties, which make it a time-tested remedy for urinary calculus of varied origins.

Additional Reading:

Renal Calculus – An Overview 

To get more information on and to buy K-Crush, please click the link below:

K-Crush Capsules

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